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Year : 2022  |  Volume : 34  |  Issue : 4  |  Page : 448-451

A comparison of the mydriatic efficacy of tropicamide and phenylephrine eye drops administered as a vaporized spray in one eye and conventional drop instillation in the other eye in an Indian pediatric cohort

Department of Ophthalmology, Father Muller Medical College Hospital, Mangalore, Karnataka, India

Correspondence Address:
Sunayana Bhat
Department of Ophthalmology, Father Muller Medical College Hospital, Tulasi, Near Urwa Market, Mangalore - 575 006, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/joco.joco_127_22

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Purpose: To determine by serial measurements and compare the pupillary mydriasis effect of tropicamide and phenylephrine drops administered as a vaporized spray over closed lids in one eye and through conventional instillation of eye drops in the other eye in a pediatric cohort. Methods: This prospective study was conducted on healthy children aged 6–15 years. After visual assessment, investigator 1 examined the child for initial pupillary size. Investigator 2 instilled the drops in one eye and applied the spray to the other eye randomly, and the response of the child was noted using the Wong-Baker pain rating scale. The eyes receiving the spray and the eyes receiving drop instillation were considered as Groups 1 and 2, respectively. Subsequently, serial pupillary measurements were carried out every 10 min for up to 40 min by investigator 1. The patient compliance for the two methods of drug instillation was also compared. Results: The study comprised 80 eyes. At 40 min, both the groups showed no statistical difference in the mydriasis effect, with Group 1 showing 7.23 mm mydriasis and Group 2 showing 7.58 mm (P = 0.058). The analysis of the pain rating scale showed better compliance with the spray method of drug instillation, which was statistically significant (P = 0.044). Conclusions: Our study shows that spray application is a less invasive method for pupillary dilatation, which has better compliance and provides equally good dilatation as conventional methods. This study proves the efficacy of spray application in an Indian pediatric cohort.

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